Through an unbiased screen of 1520 FDA-approved drugs, we identified glucocorticoids as potent inducers of P-body formation, establishing an unrecognized connection between steroid hormone signaling and cytoplasmic RNA granule dynamics. Victoria J. Nicolini, THE FRENCH GR-P-BODY NETWORK & Patrick…
Herein, we report a divergent and efficient strategy for accessing two novel structural families of benzo[4,5]imidazo[2,1-b]thiazoles through halogen-promoted intramolecular sulfenylation of functionalized dienamines.
PCBIS vient de contribuer à une étude montrant que l'agressivité de certains cancers est plus importante chez les femmes pré-ménopausées. Les résultats de ce travail mené par l'Institut Curie viennent d'être publiés dans la revue Nature.
we describe a catalyst-free thia-Diels–Alder cycloaddition for the chemoselective labeling of fully deprotected phosphonodithioester–peptides in solution with fluorophores functionalized with an exocyclic diene. doi: 10.1021/acs.bioconjchem.2c00500
Une nouvelle publication de PCBIS : https://doi.org/10.1016/j.jconrel.2021.06.033
