Through an unbiased screen of 1520 FDA-approved drugs, we identified glucocorticoids as potent inducers of P-body formation, establishing an unrecognized connection between steroid hormone signaling and cytoplasmic RNA granule dynamics. Signal Transduct Target Ther. 11, 245 (2026).
Nicolini VJ, Dupart M, Raffelsberger W, Vidal-Cruchez O, Rete T, Jacquet K, Brau F, Abelanet S, Irondelle M, Bourdin A, Durivault J, Gotorbe C, Knittel-Obrecht A, Didier B, Villa P, Di GiorgioC, Mograbi B, Hubstenberger A, Hofman P, Brest P.
