Target libraryAvailable cellular modelsScreening DepartmentQuantification of cytokine secretion by mononuclear cellsNitric oxide secretion assay by murine macrophagesMeasurement of intracellular reactive oxygen species (ROS)Determination of histamine secretion by human mast cellsDetection of kinase activityMeasurement of macromolecules interactions by AlphaScreen (PERKIN ELMER)Search for interaction between a soluble protein and a ligand by fluorescence polarization measurementMeasurement of molecular interactions using Epic Label Free technologyMeasurement of receptor-ligand binding by FRETMeasurement of receptor-ligand binding by HTRFMeasurement of receptor-ligand binding in whole cells without labelingIntracellular IP1 measurementIntracellular calcium flux measurementIntracellular cAMP measurementMonitoring the growth of a bacterial strainMonitoring cell line growthMonitoring the growth of single spheroidsEvaluation of the cytotoxic effects of a compound on cell linesEvaluation of the cytotoxic effects of compounds on single spheroidsDetection of cell apoptosisScratch Wound Healing assayEvaluation of the angiogenesis process by endothelial cellsMonitoring the efficiency of a transfectionEvaluation of the absorption of a compound through the intestinal barrierEvaluation of the effect of compounds on the integrity of the intestinal barrierParticle size measurement by Dynamic Light Scattering in 384-microplateMicrofluidicsADME-ToxInhibition des uridine glucuronyl transferases (UGT)Log D (shake flask)Metabolic stability on hepatocytesPermeability (PAMPA)pKaKinetic solubilityThermodynamic solubilityFormulation studyLog D (CHI)Chemical stabilityBlood partitioningPlasma protein bindingHemolysisPlasma stabilityMetabolite identificationCytochrome P450 inhibitionCytochrome P450 inductionEvaluation of ligand binding to the hERG channelMetabolic stabilityPre-clinical analysisRelated analysisChemical libraries - Medicinal chemistryPACSIIMPReSs
