Cytochromes P450 (CYP) are the main enzymes involved in drug metabolism. They may be induced by exogenous substances, causing drug interactions.
If a cytochrome P450 is induced by a compound, it can increase the metabolism of a co-administered drug which is the substrate of the induced enzyme.
The consequence of induction is a reduction in systemic exposure and therefore in the efficacy of a co-administered treatment or of the medicinal product itself.
This test identifies the potential of test compounds to induce CYP1A2, CYP2B6 or CYP3A4, using cryopreserved human hepatocytes.
