A compound can be chemically unstable if it is degraded by non-enzymatic processes.
The instability of a compound in solution can lead to erroneous data during in vitro tests.
Compounds with high chemical instability cannot claim to become drug candidates because it is difficult to find a formulation to prevent this degradation.
| Matrix | PBS pH 7.4 or simulated gastric fluid (SGF) ou simulated intestinal fluid (SIF) |
| Test temperature | Room temperature |
| Concentration du test | En fonction de la solubilité |
| Controls | Erythromycin, omeprazole |
| Time points | 0, 2, 4, 6 and 24h |
| Analysis method | HPLC-UV |
| Data delivery | Half life |
| Replicat | 2 |
The times and the number of samples can be personalized.