A compound can be chemically unstable if it is degraded by non-enzymatic processes.

The instability of a compound in solution can lead to erroneous data during in vitro tests.

Compounds with high chemical instability cannot claim to become drug candidates because it is difficult to find a formulation to prevent this degradation.


MatrixPBS pH 7.4 or simulated gastric fluid (SGF) ou simulated intestinal fluid (SIF)
Test temperatureRoom temperature
Concentration du testEn fonction de la solubilité
ControlsErythromycin, omeprazole
Time points0, 2, 4, 6 and 24h
Analysis methodHPLC-UV
Data deliveryHalf life


The times and the number of samples can be personalized.