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  • Target library
    • Available cellular models
  • Screening Department
    • Quantification of cytokine secretion by mononuclear cells
    • Nitric oxide secretion assay by murine macrophages
    • Determination of histamine secretion by human mast cells
    • Detection of kinase activity
    • Measurement of macromolecules interactions by AlphaScreen (PERKIN ELMER)
    • Search for interaction between a soluble protein and a ligand by fluorescence polarization measurement
    • Measurement of molecular interactions using Epic Label Free technology
    • Measurement of receptor-ligand binding by FRET
    • Measurement of receptor-ligand binding by HTRF
    • Measurement of receptor-ligand binding in whole cells without labeling
    • Intracellular IP1 measurement
    • Intracellular calcium flux measurement
    • Intracellular cAMP measurement
    • Monitoring the growth of a bacterial strain
    • Monitoring cell line growth
    • Monitoring the growth of single spheroids
    • Evaluation of the cytotoxic effects of a compound on cell lines
    • Evaluation of the cytotoxic effects of compounds on single spheroids
    • Detection of cell apoptosis
    • Scratch Wound Healing assay
    • Evaluation of the angiogenesis process by endothelial cells
    • Monitoring the efficiency of a transfection
    • Evaluation of the absorption of a compound through the intestinal barrier
    • Evaluation of the effect of compounds on the integrity of the intestinal barrier
    • Particle size measurement by Dynamic Light Scattering in 384-microplate
  • Microfluidics
  • ADME-Tox
    • Log D (shake flask)
    • Metabolic stability on hepatocytes
    • Permeability (PAMPA)
    • pKa
    • Kinetic solubility
    • Thermodynamic solubility
    • Log D (CHI)
    • Chemical stability
    • Blood partitioning
    • Plasma protein binding
    • Hemolysis
    • Plasma stability
    • Cytochrome P450 inhibition
    • Cytochrome P450 induction
    • Metabolic stability
  • In vivo studies
    • Related analysis
      • Analysis on mice
      • Biodistribution and passage of the blood-brain barrier (BHE or BBB) in vivo
      • Safety assessment (MTD)
      • Pharmacokinetics
      • Histology
      • Analyzes on biological samples
  • Chemical libraries - Medicinal chemistry
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