Lipophilicity influences absorption, and tissue distribution of a molecule. Hydrophobic molecules exhibit high propensity to non specifically binding to plasma proteins and to become metabolized by cytochromes P450.
The partition coefficient between octanol and water is the most widely used physicochemical determination of lipophilicity.
This test consists in measuring the octanol/water partition coefficient of a compound. The value determined informs about the lipophilicity of the molecule. The log D is a function of the pH. Its value must be indicated at a given pH.